AFAIK there are no hp reducing one handed weapons, only icons get -hp. It is possible to get random blue/purp/gold drops with -hp... but I've only seen those get up to "32" once... not the -50 from the mission one. So I suppost theoretically you could get one higher, but it would be extremely rare. And yes, as of now the 55 hp build is the lowest.
-Spoonman
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